With the right load, stout powder charge that still is accurate, lots of practice and I would say 10-14x optics 200-300 yards would be possible. Perhaps longer.

A friend of mine is shooting an Encore .50, topped with a Leupold VX-III 4.5-14x50mm setup with the ballistic reticle and his load iswith 125gr 777 2FG and a Hornady SST 250gr projectile. His max range is 300 yards and he has effectively and routinely harvested deer at 200 to 300 yards. He is sighted zero at 200 yards and practices a great deal shooting at these ranges. Hisaverage shot opportunityis really 200 yards with the longest at 300as he is hunting 10 acres of woods that is across an open corn field. The deer are almost never standing around closer or if they are they are already running at top speed so a shot is not possible. He also carries in his blind, the exact same setup only with a 3x-9x VXII for everything under say 150 yards, which is a rare occasion. He has only harvestedtwo deer in the past four years under 150 yards.

What you will find if you routinely wish to shoot atextended rangesis you need either to sight in at around 200-250 yards or have a quality drop compensating reticle scope and higher maginification and a bunch of regular shooting practicein my view.

I have targeted out to 300 yards with a couple of my inlines (from my friend's blind)with actually pretty good accuracy from a bench, but I only have 9x optics so really it's very difficult for meto shoot with any real precision.

M2C