anything small that you will carry. sounds obvious but a lot of people get 1911's and find out that its to big and heavy to carry on a regular basis. also, self defense is usually up close and personal...within feet not yards distance. any small frame pistol in 380, 9mm, 40 or 45 made buy a quality company on a quality design is the way to go. even a small frame 38 spl fits the bill,DO NOT bet your life on a cheap, poor quality gun.