If...and that's a BIG IF...I ever went to Africa to hunt the big mean critters, I'd want to take either a Mauser actioned or double rifle, in a caliber that starts with a "4", or at a bare minimum a .375cal. It'd be loaded with RN solids to make sure it's going to find its way to vitals. The rifle would have open sights. Accuracy wise, the more the better, but I'd be satisfied with 3-4 MOA. I haven't been to Africa, but I imagine that shots aren't that far, and the vital area on an elephant would be enormous.

Mike