I haven't shot any of the handguns you mentioned in your post. But I have heard good reports on the 460 and 454. The 500 is a bit much for deer IMO. But dead is dead for sure. The recoil for these guys could be pretty stout for someone not used to shooting a big bore handgun.
The handguns I use for hunting are the S&W 29 8 3/8" in .44 and the T/C Contender in 7-30 Waters or 35 Rem. All 3 of these have accounted for enough deer that I know they are more than adequate. The Contender gives me a bit more range. Good luck on your selection and let us know how you like whatever you choose.