The 460 gives you the best of the .460 S&W, 454 Casull, and 45 Long Colt. You can essentially shoot any of the above three out of that one gun.

That being said, be forewarned, any handgun with a compensated or ported barrel is going to be very very LOUD when you shoot it. Unless I am looking at a gun for target shooting only, my preference is for a non-ported barrel.