I know several people who reload the XTPs in their .45 ACP and 454 Casull. I have also seen what XTPs will do to a mule deer and hog from both a 454 Casull, and a .50 cal muzzle loader, and I personally think that it would sweep a man clean off his feet in the event of an attack. If I were loading a self defense round I would rank the XTP near the top of my list.