There is no way you will go wrong with either caliber. I have thinned my hunting caliber selection down to 22-250, 30-30, 308, and 270. I am keeping both 308 and 270. I have been killing deer for 25 years with a 270 and accumulated an even 100 deer body count as of Wednesday. The only reason I am keeping the 308 in my selection is for the heavier bullet weights available for 30 cals. I have always used 150 gr bullets in my 270 and have loaded a few of the Nosler PT 160 grs, but I do like the option of being able to shoot 180-220 gr bullets if I ever needed to.

If I HAD to only keep one or the other, I would keep a 270 (mainly because my favorite rifle is chambered in it and I reload for it).