As Arthur mentioned, holding weight is a larger factor in my shot sequence than the actual draw weight of the bow or the actual letoff.

I prefer a holding weight right around 18-19#. This means that on my target rig with 65% cams that I end up with a peak draw weight of right around 54#. For my 75% letoff hunting bow, that puts the draw weight at about 72#.

When I don't have enough holding weight, my shot is not steady enough. With too much, I end up getting fatigue earlier than I would like.