I shot a deer one time that was quartering to at a pretty sharp angle. The lungs were screened by the shoulders, which I didn't want to try to shoot through at that angle, but the deer was 5 yards away and stationary, and I was at full draw. I hit it at the base of the neck, where the neck joins the body, and it was a good solid hit. The deer tore out of there at maximum velocity, went about 40 yards and died. Bear Razorhead. I would take that shot again, no problem. I might even try it on a broadside presentation if theribcage were screened.

The spinal column is 2+" in diameter, and if you hit it squarely you will drop the deer. If a glancing hit high, he'll escape and recover. A glancing hit low should sever the plumbing. This is certainly not a preferred shot selection, but if you can make the shot it will be effective.