I am signed up for a Bison hunt out here in January. It sounds like a little more of a "hunt", as the animals are free ranging over a number of square miles - butis still a canned hunt in the sense that they can't really get away. I am told that the shot to take is to wait for animal to step forward, with the front leg that is facing you broadside or slightly quartering away, and put the arrow kinda low in the armpit of that leg. Bison are anatomically different than deer and elk, and have their heart/lung area quite a bit lower and further forward than you would expect. They are also pretty tough. A buddy of mine shot one in the chest with a .416 Rem Mag and the bull looked at him as if "Is that all you got?" There was a deal on Outdoor Channel awhile back where Ted Nugent shot one a couple of times with his Magnus Stingers and wound up trailing him for most of the morning before he finally expired.

BTW, for my taste buds, bison is about the best tasting meat on the planet.