For an all around varmint rifle, i would choose between the .223 ackley imp., the .204 ruger, .17 rem., the .221 fireball or the .220 swift. Out of those i dont really know, i guess it would be either the ackley, fireball, or the ruger. I personally reload and hunt for the fur. A 22-250 has got speed ill give it that, but the bullet deflects to easy and leaves to big a hole for fur hunting. Ptherwise I would have one in no-time. I would rather have a 22-250 than to have a 270 or a 7 mag for varmints. lol