Don't forget about the Barnes bullets all three are great, I currently shoot the Spitfire because I read somewhere (chuckhawks site I think) that they are slightly smaller and easier to load in the tight bored Omega/Encore. They are still plenty tuff to load (I personally can't tell that they are any easier to load-I usually look like this while loading [:@]) but shoot great.
Some guys like 300 grainers and others 250 grainers, I myself am a 250 man for deer. My spitfires I think are 245gr. with a BC of .203
I started out with shockwaves and still shoot them at the range, they group really well in my gun. But I think if I were to buy some for hunting I would get the bonded ones (blue tip). Shot a doe with a regular SW there was an exit but not a big one and the wound channel was littered with fragments, it did the job but I prefer a bullet that will hold together.
I have no experience with the Speer GDHP but have seen some impressive pics of recovered bullets and alot a people on here seem to really like them.
Here is a buck I took year before last with a Barnes Spitfire 245 (didn't sqeeze the trigger last year)