Shot placement is critical when hunting hogs. i have killed a few hogs with a .22 rimfire at close range and a lot of them with a .22 Hornet: However, most have been killed with a .50 M/L and the .430 240 grain XTP bullet.Just aim for the area between the eye and the ear. If you can put a bulletthere ear you got him.

Do not think deer anatomy when shooting hogs: They ain't the same. Hogs can be very hard to kill if the shot is not placed right: i,ve seen them run away after being shot with a .300 Weatherby Magnum and a 180 grain bullet. Here is a good thing on hog anatomy:

http://www.hunting-in-texas.com/learnhogs.htm#anatomy