Being a Ruger I' m assuming your 10/22 is pretty accurate, basically what' s going to limit your range is the " stank" on your ammunition, no usually the problem with high powered centerfire rounds, where accuracy is usually the range limiting factor. It' s not a good gun for yotes, but it will work, I' ve used .22lrs on several yotes, and have never had one get away, but I haven' t missed the ear....yet. I' d say AT MOST, the longest shot you should even consider would be 50yrds, it may do it at longer distances, but I wouldn' t try it, never have, and probably never will, however, I have taken yotes with .22lr' s at 50yrds, and they didn' t get far if they ran at all. Important thing to remember is to either hit the ear (where the skull isn' t very thick on the side of the head) or to get a good heart shot on a quartering away yote (.22lr will not penetrate the shoulder muscles, you might get lucky, but it' s best to go through the thin walls between the " floating" ribs, and then head for the heart, only way to do that is a quartering away). One thing I' ve done in the past, when I got a good quartering away shot on a large coyote, is double tap it, I can bump fire my marlins to empty 10 rounds in less than 3 sec or 17 in less than 5 (in my two favorite guns), so I can double tap the same tin can before it falls off the fence at 75yrds. Get good at that, and you increase your ability to take yotes.