If you are going to hunt on a clean barrel then you should sight in or at least know for certain where it will hit each time, on that clean barrel.

Some people claim if you load the rifle and then take a patch with a "LITTLE" bore butter on it, and swab down to the projectile, it will act as a fowling and make them all shoot in the same place. I tried that I never found it ot be the case.

What I do is learn where the rifle will shoot on a clean barrel, if I decide to hunt that way. Today I hunted a clean barrel and I know the rifle will shoot about an inch low. Well an inch at 50 yards means nothing to me. I aim dead center kill zone and let fly.