Falcon is correct, the 168 Sierra is a "Match" bullet and should not be used for Big Game. Plenty of great hunting bullets available without using target bullets.
H 4350 and IMR 4350 are both very popular powders for the 06, but only "Your" rifle can tell you if it is the best choice . Every rifle is different and what works in my rifle may or may not work in yours. Load development and testing is the only way to find what your rifle likes and dislikes. The 4350's is a good place to start, but you may have to move on and try another powder or two to get the accuracy you are looking for. Same goes for bullets. Your rifle may like the 165's or it may prefer a 180 or a150.