In my experience yes...but not the way you are thinking. I have see deer in the late cold season take different route to avoid the cold wind, but as far as purposely changing trails/direction for scent purposes no. Usually only after danger/suspicion that something is up do they circle and get downwind of the problem area.

Also, when you thinkk about it, ou still want the wind in your face regardless of whether the deer are changing routes or not.