If the slug gun has a rifled barrel I would try it and see how well it does with several brands of slug some of the better ones are deadly at 100yds; if its not a rifled barrel then you are better off with the 45 muzzleloader, a 50 or especally a 54 cal. would be much better in a PRBthough if the laws where you are allow it you might try a 40 cal bullet in a 45 sabot or if its a 1-48 twist a Real bullet usually works quite well. Lee