The 165's are great I would go for one of the better constructed bullets though.BigCountry mentioned the gamekings or the core lokts. Look at where your friends are shooting their deer too a few inchs can make a world of difference. And no there is no magic bullet.

I read of two vets in Africa that did an experiment while thinning out a buffalo herd. They used a 338(small for buffalo)and made note to see which one died on the spot and which ran. They found that even with a small bullet if you hit an animal at the instant its heart beats its blood preasure will spike bursting all the blood vessels in the brain causing instant death. Just something to think on about the 243 dropping them.