Sight in with the bullet you will hunt with first. Sight it in 1" high at 100 yards with this you will be dead on at 50 inch high at 100 and dead on at 200, anything from 25 to 250 yards will be point and shoot. Use 140's if you want I do but find what your rifle likes best and stick to it. Just a note the 270 was designed aroundthe 130 gr. bullet.