I think the heavier PRB can do that, the .45 can't from my experience in shooting a .45 cal FL for a while. I like the .54with a PRB, much more energy.
Chap Gleason
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Yeah I agree that bigger is better in this scenario however, my .45 has brought down a lot of deer. Did have to track them though-but never did lose one. That was my first ML so at that time I didn't have a choice, now that I own others its not the first one I pick out to take deer huntin'(Now it's my fall turkey gun)

Just a side thought, I wonder where the idea of a PRB isn't effective came from? When I first got into ML that was the only thing people used now people speak as if you're better off w/a creek rock. Not that it makes any difference to me just curious...