No question .22wmr I really dont like the .17hmr for coyotes.I have killed around 20 with my .22wmr and watched 10 or so run off with a .17hmr.I try to keep my shots under 100 yards or less.I use it mainly when I am calling and they come in close.My bother-in-law uses his 17 and it just hasent worked very good.I have some video of our hunts if I can figure out how to put 8mmtape on here.