I wouldnt worry about any well placed shot out to 75-100 yards. I wouldnt use hollow point bullets in it though. Ive found that jacketed soft points are very good hunting ammo for a 44 mag. We tryed hollow points on deer for a few years and they didnt perform too well. I use my 44 mag handgun as bear protection when hunting so i want a bullet thats going to do its job.