Thats what I shoot out of my Remington 700MLS .50cal.I use 100grns of 777 and they work great! I have killed several deer with them and they perform great.

Wish I could have told you about a 250lb. hawg this year but he ran off before I could get a shot[:@]

I am thinking of trying the 300 grainers too but the 250s rock!. BTW Knight also sells the same bullet for about $2.00 more a pack called the " Red Hot Bullet" same bullet different package