I have a 10ML-II too, and I wouldn't attempt it even with the hottest loads. The problem come in with how do you zero the rifle. If you zeroed the rifle at 300 yards, it'd still be one heck of a shot unless it's dead still and you have the exact range. Even 10 yards off on a range estimate will be about a 3" high/low. 20 yards off and you've probably (hopefully) missed completely. Combine this with the fact that just makeing a good POA=POI shot at 300 yards in field conditions with a sub-MOA rifle is very hard, and you might as well just close your eyes, pull the trigger and pray.

Mike