"Best" in my opinion is Nosler Partition HG 300g Protected Point, Crushed Rib sabot, 100g of 777, Winchester Primer:

http://www.the-gleasons.com/noslerpartition300g.htm

This was shot into a 6 pt, quartering toward me in the brisket and shot thru the whole deer to the off side hind quarter, under the hide. Extreme penetration, perfect expanion, very little WT loss.

Chap Gleason