For a 22-250 the 16x would be at the high end needed and comments about the light dimming and distoration becoming a factor are dead on.Use a quality scope(Vari X lll,Bushnell 4200,Nikon,Zeiss,Weaver)and stay in the 4.5x14/4x16 area.This will work well out past 500yds where the 22-250 begins to wander in the wind some what.I have a VariXlll 4.5x14x40 on one 22-250 and a 3.5x10x44 on the other and prefer the 3.5x10 the most.

woods