I'll be ordering my #1 in .405 shorty I hope. Wanted one for quite a while now. Mostly just for a plinker and for the classic style rifle with the classic cartridge. I'll reload so ammo isn't a big issue. I have 3 other #1's currently, one of which is a .45-70. Great shooter and also another great classic cartridge. If you're not to be relaoding, I'd sugegst going with the .45-70 just becasue of the wide availability of ammo. All the major ammo makers have a few laods for it and it is less expensive. Plenty capable of any game on this continant too.
if you are yo relaod, I'd even sugegst maybe a .458 Win mag #1. heavier than the .45-70 one a dn you can load down to .45-70 levels while still being quite capable of the full .458 loads should you decide to head to Africa.