This might be a stupid question, but I will go ahead and ask it. Will a 50 cal blackpowder firing 295 gr powerbelts and 100 gr triple 7 powder shoot flat at a 100 yds?

The reason I ask is where I will primarily be hunting in the woods, my max shot will not even be 75 yds. If it doesn't shoot flat and I sight in at 100 yds, won't I be low on shots under 75?