Right now I just have a few rifles, a 10/22, a Ruger M77 .243, and an old sporterized Enfield that a friend gave me, but I'm trying to plan out the cartridges I'd like to buy guns for in the future. I have two young sons who I can't wait to take hunting with me here in 5-10 years and so having 2-3 cartridges that can take each of the major game animals is what I'm looking for.

My next purchase is going to be my go to gun. The one gun that I want to be so confident in, and comfortable with that I could take anything with it from deer to bear to moose. I'm still undecided on the caliber, but am leaning towards .308. I'm thinking of a Tikka T3 synthetic/stainless topped off with a Zeiss Conquest 3-9x40. I'm still not dead set on the .308, but I want something that could handle Elk/Moose, but not be overkill for deer/antelope. Here are the other cartridges that I'm thinking about after that. I'd appreciate any input. You've probably noticed that I don't have an african caliber listed. I fully plan on an African trip in 5-10 years, but I'll probably buy a gun just for that hunt as I think the recoil will probably be so bothersome that I won't want to use it for anything else. Oh, I also intend on getting into reloading in the next year or two, and so that's why I'm kind of leaning towards short-action cartridges, just to keep things uniform.

.22 (have)
.223, .204, or .22-250
.243 (have)
7mm-08
.308
something between a .300wsm and a .338winmag