150, 165 or 180 gr bullets are all fine for deer. As far as bullet construction goes any standard construction bullet will do just fine. For handloading you'll need to develop the load your gun likes best. That means finding the bullet and weight your gun likes best. 4064, 4350, 4831, RE 19, RE22, 748, 760 are all great powders. That's the great thing about handloading there are all kinds of variations that you can try. Buy a reloading manual and follow published load data and you'll find a load your gun likes.