Sometimes you pick a bullet for hunting but your rifle will not shoot it well, no matter what you try.
So first is to find a bullet for hunting that your rifle likes.
I start all my loads just off the lands then work on the powder.
Next is powder and the correct amount. Most loads have a sweet spot where accuracy is best, changes of a grain can impact accuracy. I have reloaded for many mid range big game cartridges and H-4831 is a very consistent powder for accuracy. Always a good place to start, and start a few grains below published max loads and work up.
I usually stop here for hunting loads. I always use Remington Brass and Federal BR large rifle magnum primers and H-4831.
This combo has never failed me yet and I like to keep it simple.
If at this point your bullets are not showing promise go back and try another bullet.

For fine tuning a promising load then:
Tweak distance from lands.
Try other primers.
Here is where it can get really time consuming as each of these activities can affect pressures so you need to decrease powder with each change and work up.