RE: Velocity or weight?
I use my 45-70 with a 405 grain remington soft point at 1500 fps for brush hunting feral hogs. The reason is not that it will penetrate brush but that this load will give me total penetration from any angle. For deer hunting I use with my 7mm mauser and 30-06 I push medium weight bullets to 2600 fps, this gives me a useful trajectory to 250 yards and somewhat lessened meat damage and good penetration. My 300 Win mag gets 200 grain bullets pushed near 2900 fps for any open country elk hunting I do. My long range mulie needs are met easily with loads featuring 150-165 grain bullets with velocities of 2850-3000 fps.