IMHO I wouldnt try the reduced loads with H110 anyways, that is a high performance powder and is intended for high performance loads. Using a powder like the Trail Boss by IMR that I recomended earlier would be a much better choice. Why might I ask are you insisting on the H110, is it because it is what you have right now? I have shot with the H110 as low as 18 grains with success, but that was in my 1894 Marlin, not in a pistol.