You are shooting 400 spine Axis arrows. What draw wt. is your Dren? If #70, the arrows are probably underspined.

Other things to look for would be broadheads not spinning true, or fletching without offset or helical

IME, Slick Tricks are more likely to give you field point flight and accuracy than Muzzys, especially with a slightly out of tune bow. Muzzys can certainly be tuned to shoot well too.