Ok well as many know I put a Muzzy Zero Effect on my bow. It is awesome and I love it. But I have a question...(eventually)

So it's shooting really good. Arrows enter target straight and everything looks fine. Last night I decide to shoot broadheads first time, this year.

They are hitting good, grouping with my target tips out to 40 yards. Since I always shot a 2 prong rest. The cock vane was always down. Well now I have a drop-away does it matter?? I shot a couple with the cock vane up. They were consistantly 2.5 inches high..tried it with target tips..still high not quite as bad. Does this indicate a tuning issue? Should it shoot the same either way? The only other factor involved was a strong tail-wind gusting probably to 20 mph.