If you live out of town and think you can get real close then maybe, but that is a big maybe IMO. I would error on the safe side and say no though. What is your reason for doing this is what you need to ask yourself. If you live in town then I would say a big no no!! The last thing you need is a tree rat running from your yard to the neighbors yard with a ten inch dart dragging out of it's rear end. That would be bad publicity and could get you in trouble with the police or neighbors real quick. If you live in town and have a squirrel problem that you need to work on then I would get a good 100 dollar BB pellet gun and you should be able to get the job done in close range and are quiet to. Also if you did have a bad shot then you would not have a arrow dragging by the back side causing problems for you. I would say if in town, live trap, then pellet gun if you must. Out of town maybe, but why not a .22? You just need to think of a bad out come and the less evidence the better for you.