Paul, their is nothing wrong with any of your listed cartridges for the purpose you stated "medium range woodchuck/target...". You really don't need a .243 for this purpose. I currently have a .22-250, and have previously owned a .243. The .22-250 will give you all the range of the .243, and will put less into your shoulder. I love .243's, but if you are not going to hunt anything larger than say woodchucks, coyotes, ground squirrels etc., its really hard to beat a speed of light .22 for the maximum production of red wind after the hit. As stated previously, the .243 has a few factory loads available in 50 grain or so bullets, but this is more the territory for .22's. Really tough though to make a bad decision here. The .223 is superb if you will be shooting a lot, and shots will not go much beyond 250 yards IMHO, recoils less than the .22-250, 200-300 fps slower than the .22-250, same bullets.