Normally like to keep my shots at 40 or less. But I had a perfect opportunity for a 50 yarder a couple of years back. I was shooting a Muzzy 3 blade, 100gr - with my bow shooting around 240 FPS.

The broadhead actually went through the front shoulder bone and directly through the heart and stuck out through the rib cage on the other side…

I actually saved some pics of the broadhead. It got dung up going through all that bone, but it still did the job!

http://www.southdakotahunter.com/pics/broadhead1.jpg
http://www.southdakotahunter.com/pics/broadhead2.jpg