For deer within 250-300 yards they are just fine. And that is way further than most will shoot regularly (unless you're shooting beanfields). Unless you are shooting a firearm with incredible velocity they will serve you well, provided you are satisfied with the accuracy they can provide in your rifle.

Most guns shoot better than most shooters, and most commercial bullets do an excellent job.
Just be sure that your intended quarry is within the boundaries of the core-loct capabilities. For most deer hunting, heck for most hunting period, they will suffice.
When you wander into bear country or are going on a hunt of a lifetime for bigger stuff, you'll find better choices.
It's all about velocity, bullet construction, and what you plan to punch a hole in. That said, most Winchester, Federal, and Remington offerings on the shelves have been tested until the cows come home.
This is not to say there aren't superior items available for special purposes. It's just that the bigger commercial companies pretty much know their trade. And they offer the upgrades anyway.
Handloading can always provide you a better product as long as you know what you're doing and realize that it will be mostly an accuracy improvement rather than a cartridge terminal performance issue.