ORIGINAL: Narient
How about a 1000 lb Grizly with CCI 22 Cbs
Don't laugh too hard. A world record grizzly was taken by a little girl back in the 50's with a .22 short. If you'd like I can find the documentation for ya.
Couldn't believe it so I used Google... Bella Twin killed a huge grizzly with a .22 in self defense in 1953. This site has a picture, story is about 3/4 down the page:
http://www.brassmonkeyproductions.com/grizzly/Part3.html