RE: 22 Hornet
I have been using the Rem. 45 gr Hollow points with good success on deer and hogs, and they shoot great out of my NEF. I would start there.
I put one straight through a 4x4 at 10 yds, it went through a phone book at 10 yds also, so you wont have any penetration issues with the hollow point and they kill nicely. I would keep my shots to 200 yds for yotes, mainly because of the drop, at 200 I believe its like 7 inches with a 100 yd sight in.