Not only has it to do with your size but it also has to do with your shooting experience. Just because you may be a big guy, you should consider your own experience with guns.(this you have not stated) I would hate to have you or anyonepurchase a gun with too much of a kick and develop a bad flinch. Whether it be a 22.250, 30-30, .243,.270, or a 300 mag, they all kill deer. Different models fit different people differently. This may seem like common sense but you would be surprised at how many choose a gun that isn't right for them. Also consider the type of terrain you will be hunting, that too should be a consideration when you are choosing the cal. you wish to hunt with. I feel as at home using my 30-30 in deep thick buch as I am using my 7mm mag looking down a long tree line.If you have the opportunity to try a few different cal. and models at a range that may give you some great feedback. Good luck with your purchase.