Honestly, you aren't going to negatively affect a string with twists unless it is physically starting to kink. The only negative side affects can be that if it is twisted at a faster rate outside the served area, sometimes it can be a chore to get your peep to stay alignedat both static and full draw. Three twists to the string/one to the cables should keep the timing relatively close, but look at those timing marks before doing anything and make sure it is somewhat close when done adding twists.