In standard loads and short bbls even the 300s get doggie . Presumed Hyde had the Smith already . I'm a ruger guy too . I'd have a 454 or 460 in grizz county , presumed blacks or lil browns and a suited load to hunt on purpose . The big flat nose makes a big hole with 400 ftlbs of shock damage give or take 25lbs with 250s at the top end of std 45 colts .