I have taken two, one of them was over 600# both with PRB 54 cal. 120 gr RS they only went 30 yds [approxmate] two with bow [most fun] 7 with HP rifle. Would like to take one with pistole some day.
I have two suggestions for you , #1 is to get a vitals drawing and study it the vitals are located a bit different than a deer,# 2 the SW or Speer gold dot through both lungs, as to weight the 300 is hard to beat if your gun likes to shoot it accurate; Placement of the shot is the most important. Check this out. Lee
http://www.theidahosportsman.com/bear%20anatomy.pdf