I shoot a Winchester 88 284 the load is IMR4350 The bullet is a cheap speer 145 gr spizter I aim where the heart is surpose to be , the bullet clips the heart the deer runs at the most 100 yards most of the time the bullet passes through or hangs up on the hide on the other side , most of the ruined meat is on the ribs havent lost a deer yet you can tell if its a heart shot by the way they hump up , if you shoot a deer with a 22 cal and it hits the heart the deer is dead period maybe not right there but if your pump has a hole in it it will pump till its dry .the trick is to study the animal and find where the heart is .thats my to pesos worth