I shot a very large Canadian moose with my .280 Remington using Nosler 160 gr Accubond(handloads) at approx. 50 yards and was quite impressed with the bullet performance. I shot the bull high in the shoulder and he never took one step thereafter. I did put another finishing round in him as I approached the downed animal, simply because it was late evening and we were loosing light fast(probably wasn't necessary though). I recovered one of the slugs in the body cavity and it retained close to 80% of it's weight which at that close range I feel is very satisfactory. Neither bullet exited which is to be expectedconsidering the range, velocity and size of the animal. Thebullet is also remarkably accurate in my rifle as well, I believe it is the most accurate bullet I have tried out of about 6 different weights and styles i have tried. Good Luck, give them a go!