I'll second the vote for the Whelen. It can produce higher velocities with lighter bullets like the 180 grainers, but can handle bullets of up to 300 grains if you can get them. It has the legendary knock down power of the .35 bore, but doesn't hurt your shoulder like the big magnums. It can even be had in a quick shooter if you're hunting the thick stuff in the east.

It can shoot accurately and effectively beyond my ability to shoot it, but others would probably be better able to comment on those aspects.