Both the .257Roy and the 25-06 are fantastic deer choices. The Wby has a 150-200fps advantage w/ common bullet weights when fitted w/ a 26" tube, but the Vanguard has a 24" bbl regardless of caliber so the advantage would probably closer the 100-150fps. I'd buy the 06', but you would be happy with the Roy as well if you don't mind paying twice to 3 times as much for ammo. Brett